Written by Dr. Daniel Yetman, PhD. August 9, 2021 Introduction Top-down proteomics refers to mass spectrometry analysis of samples containing undigested or whole proteins (3,4). It’s typically executed with high resolution matrix-assisted laser desorption ionization (MALDI) mass spectrometers, but an orbitrap relying on electrospray ionization (ESI) may also be used (3,5,6). In contrast, [...]